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Sinusitis Clinical Study #1
• Sanders and Taub conducted a double-blind study of 60 people to determine the effectiveness of proteolytic enzymes on chronic sinusitis sufferers.
Proteolytic enzymes are known for their anti-inflammatory and anti-edema activity. There was marked relief in a large majority of the patients after the sixth day of treatment. Nasal breathing had become less difficult and the redness and edema of the nasal passages receded. Headaches became less pronounced and nasal secretion more liquefied.
Another study involved enzymes therapy done by R.E. Ryan and published in the journal of “Headache”. 48 patients with acute sinusitis or nasal mucosal inflammation, nasal secretions, breathing difficulties and associated headache participated in this study.
Mucosal inflammation was reduced in 83 percent of those using enzymes therapy, as compared to 52 percent of those receiving the placebo. Breathing difficulty was relieved in 78 percent of the patients on enzymes therapy, as compared to 68 percent of those on the placebo. Headaches, too, improved in the enzyme therapy group (87 percent compared to the placebo group 68 percent).
To learn more about proteolytic enzymes therapy click here.
References:
S.J. Taub, “The Use of Ananase in Sinusitis-A study of 60 Patients,” The Eye, Ear, Nose, and Throat Monthly 45:96-97 (1966).
R. E. Ryan, “A Double-Blind Clinical Evaluation of Bromelains in the Treatment of Acute Sinusitis,” Headache 7:13-17 (1967).
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Sinusitis Clinical Study #2
Fifty-nine patients with acute or chronic sinusitis, most of whom had an allergic background with superimposed bacterial infection, were randomly assigned to receive, in double-blind fashion, an enteric-coated bromelain preparation (Ananase; 40 mg 4 times per day) or placebo for six days. The proportion of patients who had an excellent response was significantly higher in the bromelain group than in the placebo group (69% vs. 23%; p < 0.01).
Comment:
Bromelain is an extract of pineapple stem that has anti-inflammatory and fibrinolytic activity. Through its depolymerizing action on fibrin and other inflammatory products, bromelain appears to increase the permeability and reduce the viscosity of inflammatory exudates, thereby promoting drainage and enhancing access of antibacterial agents to the site of an infection.
The enteric-coated product used in this study was a prescription medication that is no longer commercially available. Non-enteric-coated bromelain would presumably be partially inactivated by gastric enzymes after ingestion. While clinical experience suggests that currently available bromelain products have beneficial effects, dosage comparisons with Ananase are difficult. For non-enteric-coated bromelain, a dosage of 250-500 mg, four times per day would be reasonable for the short-term treatment of sinusitis.
Personal comments:
Bromelain supplement by itself is not as effective as bromelain micro-blended with other anti inflammatory enzymes. The two types of enzymes supplement I recommend have bromelain in the ingredients plus an assortment of other digestive and proteolytic enzymes and are also micro-blended with organic mineral rich food since enzymes require minerals to work effectively in the body.
Taub SJ. The use of bromelains in sinusitis: a double-blind clinical evaluation. Eye Ear Nose Throat Mon.1967;46:361-365.
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Sinusitis Clinical Study #3
Recognizing that antibiotics disrupt microbial balance, an Indian research team, led by Suresh Kumar, MD, tested the use of a probiotic combination to prevent Candida overgrowth in 144 critically-ill children, age three months to 12 years, as an alternative to pharmaceutical anti-fungal drug treatment. Pharmaceuticals promote resistant strains, have adverse effects, and cost more. Children enrolled in this 2013 double blind, placebo-controlled study were being treated with broad spectrum antibiotics for at least 48 hours. The probiotic preparation, which was given twice daily for one week, included Lactobacillus rhamnosum, Bifidobacterium longum, Bifodobacterium bifidum, Saccharamyces boulardi, Saccharomyces thermophiles, and fructo-oligosaccharides.
The authors report a statistically significant increase in Candida colonization (from rectal swabs) at day 7 and day 14 in children receiving the lactose placebo, but not in the probiotic group: “…concurrent administration of probiotics for 1 week in critically ill children receiving broad spectrum antibiotic therapy decreased the prevalence of Candida colonization by 34.5% on day 7 and 37.2% on day 14.” Also, prevalence of candiduria, a marker for systemic candidiasis, was 50 percent less in the probiotic group compared to control. The authors say, “Concurrent use of probiotics with antibiotics should be evaluated as a strategy to reduce the Candida colonization and prevalence of candidemia in critically ill children, in a multicentric study.”
Kumar 5, et al. Evaluation of Efficacy of Probiotics in Prevention of Candida colonization in a PICU-A
Randomized Controlled Trial. Critical Care Medicine. February 2013; 41(2): 565-572.
Martins N, et al. Candidiasis: predisposing factors, prevention, diagnosis and alternative treatment.
Mycopathologia. 2014;177(5-6):223-240.
Townsend Letter – Nov. 2017, pg. 22
Proteolytic enzymes are known for their anti-inflammatory and anti-edema activity. There was marked relief in a large majority of the patients after the sixth day of treatment. Nasal breathing had become less difficult and the redness and edema of the nasal passages receded. Headaches became less pronounced and nasal secretion more liquefied.
Another study involved enzymes therapy done by R.E. Ryan and published in the journal of “Headache”. 48 patients with acute sinusitis or nasal mucosal inflammation, nasal secretions, breathing difficulties and associated headache participated in this study.
Mucosal inflammation was reduced in 83 percent of those using enzymes therapy, as compared to 52 percent of those receiving the placebo. Breathing difficulty was relieved in 78 percent of the patients on enzymes therapy, as compared to 68 percent of those on the placebo. Headaches, too, improved in the enzyme therapy group (87 percent compared to the placebo group 68 percent).
To learn more about proteolytic enzymes therapy click here.
References:
S.J. Taub, “The Use of Ananase in Sinusitis-A study of 60 Patients,” The Eye, Ear, Nose, and Throat Monthly 45:96-97 (1966).
R. E. Ryan, “A Double-Blind Clinical Evaluation of Bromelains in the Treatment of Acute Sinusitis,” Headache 7:13-17 (1967).
--------------------------------------------------------------------------------------------------------------------------------------------------------------
Sinusitis Clinical Study #2
Fifty-nine patients with acute or chronic sinusitis, most of whom had an allergic background with superimposed bacterial infection, were randomly assigned to receive, in double-blind fashion, an enteric-coated bromelain preparation (Ananase; 40 mg 4 times per day) or placebo for six days. The proportion of patients who had an excellent response was significantly higher in the bromelain group than in the placebo group (69% vs. 23%; p < 0.01).
Comment:
Bromelain is an extract of pineapple stem that has anti-inflammatory and fibrinolytic activity. Through its depolymerizing action on fibrin and other inflammatory products, bromelain appears to increase the permeability and reduce the viscosity of inflammatory exudates, thereby promoting drainage and enhancing access of antibacterial agents to the site of an infection.
The enteric-coated product used in this study was a prescription medication that is no longer commercially available. Non-enteric-coated bromelain would presumably be partially inactivated by gastric enzymes after ingestion. While clinical experience suggests that currently available bromelain products have beneficial effects, dosage comparisons with Ananase are difficult. For non-enteric-coated bromelain, a dosage of 250-500 mg, four times per day would be reasonable for the short-term treatment of sinusitis.
Personal comments:
Bromelain supplement by itself is not as effective as bromelain micro-blended with other anti inflammatory enzymes. The two types of enzymes supplement I recommend have bromelain in the ingredients plus an assortment of other digestive and proteolytic enzymes and are also micro-blended with organic mineral rich food since enzymes require minerals to work effectively in the body.
Taub SJ. The use of bromelains in sinusitis: a double-blind clinical evaluation. Eye Ear Nose Throat Mon.1967;46:361-365.
-------------------------------------------------------------------------------------------------------------------------------------------------------------
Sinusitis Clinical Study #3
Recognizing that antibiotics disrupt microbial balance, an Indian research team, led by Suresh Kumar, MD, tested the use of a probiotic combination to prevent Candida overgrowth in 144 critically-ill children, age three months to 12 years, as an alternative to pharmaceutical anti-fungal drug treatment. Pharmaceuticals promote resistant strains, have adverse effects, and cost more. Children enrolled in this 2013 double blind, placebo-controlled study were being treated with broad spectrum antibiotics for at least 48 hours. The probiotic preparation, which was given twice daily for one week, included Lactobacillus rhamnosum, Bifidobacterium longum, Bifodobacterium bifidum, Saccharamyces boulardi, Saccharomyces thermophiles, and fructo-oligosaccharides.
The authors report a statistically significant increase in Candida colonization (from rectal swabs) at day 7 and day 14 in children receiving the lactose placebo, but not in the probiotic group: “…concurrent administration of probiotics for 1 week in critically ill children receiving broad spectrum antibiotic therapy decreased the prevalence of Candida colonization by 34.5% on day 7 and 37.2% on day 14.” Also, prevalence of candiduria, a marker for systemic candidiasis, was 50 percent less in the probiotic group compared to control. The authors say, “Concurrent use of probiotics with antibiotics should be evaluated as a strategy to reduce the Candida colonization and prevalence of candidemia in critically ill children, in a multicentric study.”
Kumar 5, et al. Evaluation of Efficacy of Probiotics in Prevention of Candida colonization in a PICU-A
Randomized Controlled Trial. Critical Care Medicine. February 2013; 41(2): 565-572.
Martins N, et al. Candidiasis: predisposing factors, prevention, diagnosis and alternative treatment.
Mycopathologia. 2014;177(5-6):223-240.
Townsend Letter – Nov. 2017, pg. 22
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Click here if you're interested in a free assessment. Get my advice and save yourself years of unnecessary misery.
|
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the FDA and are not intended to diagnose, treat, cure, or prevent any disease.
The material on this site is provided for educational and informational purposes only and must not be taken as “medical advice”. The information and directions in these writings, individually and collectively, are in no way to be considered as a substitute for consultations with a duly licensed physician regarding diagnosis and/or treatment of disease and are not intended to diagnose or treat any disease. Please consult with your doctor for this advice.
the FDA and are not intended to diagnose, treat, cure, or prevent any disease.
The material on this site is provided for educational and informational purposes only and must not be taken as “medical advice”. The information and directions in these writings, individually and collectively, are in no way to be considered as a substitute for consultations with a duly licensed physician regarding diagnosis and/or treatment of disease and are not intended to diagnose or treat any disease. Please consult with your doctor for this advice.
